He was strongly influenced by Michelangelo's religious paintings in the Sistine Chapel, which was being painted at the same time.
Despite his few years on Earth, he left behind a large volume of works and masterpieces and a reputation as one of the most naturally gifted painters in the history of art.
In 1511 he started painting the Stanza della Segnatura, the first of his most famous 'Stanze' or 'Raphael Rooms' at the Palace of the Vatican.
He was commissioned to paint 3 others rooms with religious art, and increasingly started to rely on his team of skilled assistants - led by Giulio Romano (1499-1546) - to help complete works.
According to experts in cinquecento art, the portrait is the first version of the celebrated Madonna of the Pearl, currently hanging in the Prado Gallery in Madrid.
The picture is now valued in excess of million.Detail from, The Transfiguration (1516) Now in the Vatican Museums.